stem cells in their environment

team >

fiona watt




Director - Centre for Stem Cells and Regenerative Medicine,
King's College London


•  DPhil University of Oxford, 1979

•  BA Hons, Natural Sciences, University of Cambridge, 1976

research project title

'Intrinsic and extrinsic control of stem cell fate'

core expertise

Cell biology


[Full PubMed list]

•  Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM, Lechler RI, Maher J, Smyth LA, Lombardi G. ‘Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant rejection.’ Am J Transplant. 2016 Dec 27. doi: 10.1111/ajt.14185. PMID: 28027623 [PubMed]

•  Hayes TF, Benaich N, Goldie SJ, Sipilä K, Ames-Draycott A, Cai W, Yin G, Watt FM. ‘Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.’ Cancer Lett. 2016 Dec 1;383(1):106-114. doi: 10.1016/j.canlet.2016.09.014. PMID: 27693639 [PubMed]

•  Watt FM. ‘Engineered Microenvironments to Direct Epidermal Stem Cell Behavior at Single-Cell Resolution.’ Dev Cell. 2016 Sep 26;38(6):601-9. doi: 10.1016/j.devcel.2016.08.010. Review. PMID: 27676433 [PubMed]

•  Natsuga K, Watt FM. ‘Galectin-6 is a novel skin anti-microbial peptide that is modulated by the skin barrier and microbiome.’ J Dermatol Sci. 2016 Oct;84(1):97-99. doi: 10.1016/j.jdermsci.2016.06.008. No abstract available. PMID: 27427436 [PubMed]

•  Weissman IL, Watt FM. ‘CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine.’ Cell Stem Cell. 2016 Jul 7;19(1):19-22. doi:10.1016/j.stem.2016.05.011. PMID: 27392224 [PubMed]

•  'CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine.' Weissman IL, Watt FM. Cell Stem Cell. 2016 Jul 7;19(1):19-22. doi: 10.1016/j.stem.2016.05.011. PMID: 27392224 [PubMed]

•  'Galectin-6 is a novel skin anti-microbial peptide that is modulated by the skin barrier and microbiome.' Natsuga K, Watt FM. J Dermatol Sci. 2016 Jun 23. pii: S0923-1811(16)30125-6. doi: 10.1016/j.jdermsci.2016.06.008. PMID: 27427436 [PubMed]

•  'Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.' Rognoni E, Gomez C, Pisco AO, Rawlins EL, Simons BD, Watt FM, Driskell RR. Development. 2016 Jun 10. pii: dev.131797. PMID: 27287810 [PubMed]

•  'A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data.' Kerz M, Folarin A, Meleckyte R, Watt FM, Dobson RJ, Danovi D. J Biomol Screen. 2016 Jun 2. pii: 1087057116652064. PMID: 27256155  [PubMed]

•  'Pelota Regulates Epidermal differentiation by Modulating BMP and PI3K/AKT Signaling Pathways.' Elkenani M, Nyamsuren G, Raju P, Liakath-Ali K, Hamdaoui A, Kata A, Dressel R, Klonisch T, Watt FM, Engel W, Thliveris JA, Pantakani DV, Adham IM. J Invest Dermatol. 2016 May 6. pii: S0022-202X(16)31141-1. doi: 10.1016/j.jid.2016.04.020. PMID:27164299 [PubMed]

•  'Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole body energy expenditure.' Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D, Protheroe HJ, Ingvorsen C, Galli A, Green A, Gleeson D, Ryder E, Glover L, Vizcay-Barrena G, Karp NA, Arends MJ, Brenn T, Spiegel S, Adams DJ, Watt FM, van der Weyden L. J Pathol. 2016 Apr 29. doi: 10.1002/path.4737. PMID:27126290 [PubMed]

•  'Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.' Lichtenberger BM, Mastrogiannaki M, Watt FM. Nat Commun. 2016 Feb 3;7:10537. doi: 10.1038/ncomms10537. PMID:26837596 [PubMed]

•  'β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis.' Mastrogiannaki M, Lichtenberger BM, Reimer A, Collins CA, Driskell RR, Watt FM. J Invest Dermatol. 2016 Feb 20. pii: S0022-202X(16)00489-9. doi: 10.1016/j.jid.2016.01.036. PMID:26902921 [PubMed]

•  'Professor Sir Henry Harris (1925-2014).' Watt FM. J Cell Sci. 2015 Dec 1;128(23):4253. PMID:26962590 [PubMed]

•  'Macrophage infiltration and alternative activation during wound healing promote MEK1-induced skin carcinogenesis.' Weber C, Telerman SB, Reimer AS, Sequeira I, Liakath-Ali K, Arwert EN, Watt FM. Cancer Res. 2016 Jan 11. pii: canres.3676.2014. PMID: 26754935 [PubMed]

•  'Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells.' Reimer A, Vasilevich A, Hulshof F, Viswanathan P, van Blitterswijk CA, de Boer J, Watt FM. Sci Rep. 2016 Jan 13;6:18948. doi: 10.1038/srep18948. PMID: 26757610 [PubMed]

•  'Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility.' Natsuga K, Cipolat S, Watt FM. J Invest Dermatol. 2016 Jan;136(1):99-106. doi: 10.1038/JID.2015.383. PMID: 26763429 [PubMed]

•  'Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity.' Kretzschmar K, Weber C, Driskell RR, Calonje E, Watt FM. Cell Rep. 2016 Jan 12;14(2):269-81. doi: 10.1016/j.celrep.2015.12.041. Epub 2016 Jan 7. PMID: 26771241 [PubMed]

•  'Mimicking the topography of the epidermal-dermal interface with elastomer substrates.' Viswanathan P, Guvendiren M, Chua W, Telerman SB, Liakath-Ali K, Burdick JA, Watt FM. Integr Biol (Camb). 2015 Dec 11. PMID: 26658424 [PubMed]

•  'A high-content platform to characterise human induced pluripotent stem cell lines.' Leha A, Moens N, Meleckyte R, Culley OJ, Gervasio MK, Kerz M, Reimer A, Cain SA, Streeter I, Folarin A, Stegle O, Kielty CM; HipSci Consortium, Durbin R, Watt FM, Danovi D. Methods. 2015 Nov 25. pii: S1046-2023(15)30153-5. doi: 10.1016/j.ymeth.2015.11.012. PMID: 26608109 [PubMed]

•  'Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility.' Natsuga K, Cipolat S, Watt FM, J Invest Dermatol. 2015 Sep 30. doi: 10.1038/jid.2015.383. PMID: 26422382 [PubMed]

•   'Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation.' Kaushal GS, Rognoni E, Lichtenberger BM, Driskell RR, Kretzschmar K, Hoste E, Watt FM. J Invest Dermatol. 2015 Aug 19. doi: 10.1038/jid.2015.319. [Epub ahead of print] PMID: 26288357 [PubMed]

•  'The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells.' Kretzschmar K, Cottle DL, Schweiger PJ, Watt FM. J Invest Dermatol. 2015 Jun 29. doi: 10.1038/jid.2015.242. [Epub ahead of print] PMID: 26121213 [PubMed]

•  'Stem Cell Heterogeneity and Plasticity in Epithelia.' Donati G, Watt FM. Cell Stem Cell. 2015 May 7;16(5):465-476. doi: 10.1016/j.stem.2015.04.014. PMID: 25957902 [PubMed]

•  'Understanding allergy and cancer risk: what are the barriers?' Hoste E, Cipolat S, Watt FM. Nat Rev Cancer. 2015 Mar;15(3):131-2. Epub 2015 Feb 5. PMID: 25866857 [PubMed]

•  'Recognizing the importance of new tools and resources for research.' Schekman R, Weigel D, Watt FM. Elife. 2015 Mar 31;4. doi: 10.7554/eLife.07083. PMID: 25824292 [PubMed]

•  'Seven actionable strategies for advancing women in science, engineering, and medicine.' Smith KA, Arlotta P, Watt FM; Initiative on Women in Science and Engineering Working Group, Solomon SL. Cell Stem Cell. 2015 Mar 5;16(3):221-4. doi: 10.1016/j.stem.2015.02.012. PMID: 25748929 [PubMed]

•  'Innate sensing of microbial products promotes wound-induced skin cancer.' Hoste E, Arwert EN, Lal R, South AP, Salas-Alanis JC, Murrell DF, Donati G, Watt FM. Nat Commun. 2015 Jan 9;6:5932. doi: 10.1038/ncomms6932. PMID: 25575023 [PubMed]

•  'Understanding fibroblast heterogeneity in the skin.' Driskell RR, Watt FM. Trends Cell Biol. 2015 Feb;25(2):92-99. doi: 10.1016/j.tcb.2014.10.001. Epub 2014 Nov 7. PMID: 25455110 [PubMed]

•  'Mammalian skin cell biology: at the interface between laboratory and clinic.' Watt FM. Science. 2014 Nov 21;346(6212):937-40. doi: 10.1126/science.1253734.PMID: 25414300 [PubMed]

•  'BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor under Steady-State Conditions.' Kretzschmar K, Cottle DL, Donati G, Chiang MF, Quist SR, Gollnick HP, Natsuga K, Lin KI, Watt FM. Stem Cell Reports. 2014 Oct 14;3(4):620-33. doi: 10.1016/j.stemcr.2014.08.007. Epub 2014 Sep 18. PMID: 25358790 [PubMed]

•  'Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.' DiTommaso T, Jones LK, Cottle DL; WTSI Mouse Genetics Program, Gerdin AK, Vancollie VE, Watt FM, Ramirez-Solis R, Bradley A, Steel KP, Sundberg JP, White JK, Smyth IM. PLoS Genet. 2014 Oct 23;10(10):e1004705. doi: 10.1371/journal.pgen.1004705. eCollection 2014 Oct. PMID: 25340873 [PubMed]

•  Benaich N, Woodhouse S, Goldie SJ, Mishra A, Quist SR, Watt FM. 'Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis.' Cell Rep. 2014 Oct 9;9(1):104-17. doi: 10.1016/j.celrep.2014.08.062. Epub 2014 Oct 2. PMID: 25284788 [PubMed]

•  'Advancing research.' Patterson M, Schekman R, Watt FM, Weigel D. Elife. 2014 Aug 13;3:e03980. doi: 10.7554/eLife.03980. PMID: 25122625 [PubMed]

•  'Modulating the stem cell niche for tissue regeneration.' Lane SW, Williams DA, Watt FM. Nat Biotechnol. 2014 Aug 5. doi: 10.1038/nbt.2978. [Epub ahead of print] PMID: 25093887 [PubMed]

•  'Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin.' Kretzschmar K, Watt FM. Cold Spring Harb Perspect Med. 2014 Jul 3. pii: a013631. doi: 10.1101/cshperspect.a013631. [Epub ahead of print] PMID: 24993676 [PubMed]

•  'Defining dermal adipose tissue.' Driskell R, Jahoda CA, Chuong CM, Watt F, Horsley V. Exp Dermatol. 2014 May 19. doi: 10.1111/exd.12450. [Epub ahead of print] PMID: 24993676 [PubMed]

•  'Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors.' Donati G, Proserpio V, Lichtenberger BM, Natsuga K, Sinclair R, Fujiwara H, Watt FM. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1501-9. doi: 10.1073/pnas.1312880111. Epub 2014 Mar 31. PMID: 24706781 [PubMed]

•  'Distinct fibroblast lineages determine dermal architecture in skin development and repair.' Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC, Watt FM. Nature. 2013 Dec 12;504(7479):277-81. doi: 10.1038/nature12783. PMID: 24336287 [PubMed]

•  'The basement membrane of hair follicle stem cells is a muscle cell niche.' Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM. Cell. 2011 Feb 18;144(4):577-89. doi: 10.1016/j.cell.2011.01.014. PMID: 21335239 [PubMed]

•  'Diverse epigenetic strategies interact to control epidermal differentiation.' Mulder KW, Wang X, Escriu C, Ito Y, Schwarz RF, Gillis J, Sirokmány G, Donati G, Uribe-Lewis S, Pavlidis P, Murrell A, Markowetz F, Watt FM. Nat Cell Biol. 2012 Jun 24;14(7):753-63. doi: 10.1038/ncb2520. PMID: 22729083 [PubMed]

•  'Extracellular-matrix tethering regulates stem-cell fate.' Trappmann B, Gautrot JE, Connelly JT, Strange DG, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM, Huck WT. Nat Mater. 2012 May 27;11(7):642-9. doi: 10.1038/nmat3339. Erratum in: Nat Mater. 2012 Aug;11(8):742. PMID: 22635042 [PubMed]