stem cells in their environment

team >

gernot walko

nationality

Austrian

role

•  Postdoc (Marie Curie Fellow)

•  wattlab blog editor

qualifications

•  Dr.rer.nat. (Doctoral degree in Natural Sciences), University of Vienna, 2008

•  Mag.rer.nat (Master`s degree in Natural Sciences), University of Vienna, 2002

research project title

'Ex vivo deconstruction of the stem cell niche in the human interfollicular epidermis'

core expertise

•  Mouse models

•  Confocal microscopy

•  Time lapse microscopy

•  Biochemistry

•  Cell culture

wattlab blog entries

•  Science in the countryside - 26 June 2015

•  New Frontiers in Regenerative Medicine Symposium - 30 October 2014

•  wattlab in the news - 14 May 2014

•  Motor neuron diseases in a dish: can we really learn anything new? - 07 February 2014

•  Peter Baker Lecture in Physiology - 19 December 2013

•  Stem Cells: from Bench to Bedside - 21 November 2013

•  King's College London Stroke Forum – Professor Jack Price: "Developing a stem cell therapeutic for stroke” - 14 October 2013

•  The European Summer School on Stem Cells and Regenerative Medicine - 03 October 2013

publications

[Full PubMed list]

•  ‘A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.’ Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman SB, Viswanathan P, Logtenberg M, Renz LM, Donati G, Quist SR, Watt FM. Nat Commun. 2017 Mar 23;8:14744. doi: 10.1038/ncomms14744. PMID: 28332498 [PubMed]

•  'Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions.' Hartmann R, Walko G, Justesen J. FEBS Lett. 2001 Oct 19;507(1):54-8. PMID: 11682059 [PubMed]

•  'Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration.' Osmanagic-Myers S, Gregor M, Walko G, Burgstaller G, Reipert S, Wiche G. J Cell Biol. 2006 Aug 14;174(4):557-68. PMID: 16908671 [PubMed]

•  'Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects.' Ackerl R, Walko G, Fuchs P, Fischer I, Schmuth M, Wiche G. J Cell Sci. 2007 Jul 15;120(Pt 14):2435-43. PMID: 17606998 [PubMed]

•  'Plectin isoform-dependent regulation of keratin-integrin alpha6beta4 anchorage via Ca2+/calmodulin.' Kostan J, Gregor M, Walko G, Wiche G. J Biol Chem. 2009 Jul 3;284(27):18525-36. doi: 10.1074/jbc.M109.008474. Epub 2009 May 6. PMID: 19419971 [PubMed]

•  'Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity.' Fuchs P, Zörer M, Reipert S, Rezniczek GA, Propst F, Walko G, Fischer I, Bauer J, Leschnik MW, Luscher B, Thalhammer JG, Lassmann H, Wiche G. J Biol Chem. 2009 Sep 25;284(39):26502-9. doi: 10.1074/jbc.M109.018150. Epub 2009 Jul 22. PMID: 19625254 [PubMed]

•  'Plectin gene defects lead to various forms of epidermolysis bullosa simplex.' Rezniczek GA, Walko G, Wiche G. Dermatol Clin. 2010 Jan;28(1):33-41. doi: 10.1016/j.det.2009.10.004. Review. Erratum in: Dermatol Clin. 2010 Apr;28(2):439-41. PMID: 19945614 [PubMed]

•  'Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna.' Walko G, Vukasinovic N, Gross K, Fischer I, Sibitz S, Fuchs P, Reipert S, Jungwirth U, Berger W, Salzer U, Carugo O, Castañón MJ, Wiche G. PLoS Genet. 2011 Dec;7(12):e1002396. doi: 10.1371/journal.pgen.1002396. Epub 2011 Dec 1. PMID: 22144912 [PubMed]

•  'Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes.' Valencia RG, Walko G, Janda L, Novacek J, Mihailovska E, Reipert S, Andrä-Marobela K, Wiche G. Mol Biol Cell. 2013 Jan 30. [Epub ahead of print] PMID: 23363598 [PubMed]