stem cells in their environment

•  Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM, Lechler RI, Maher J, Smyth LA, Lombardi G. ‘Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant rejection.’ Am J Transplant. 2016 Dec 27. doi: 10.1111/ajt.14185. PMID: 28027623 [PubMed]

•  Hayes TF, Benaich N, Goldie SJ, Sipilä K, Ames-Draycott A, Cai W, Yin G, Watt FM. ‘Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.’ Cancer Lett. 2016 Dec 1;383(1):106-114. doi: 10.1016/j.canlet.2016.09.014. PMID: 27693639 [PubMed]

•  Watt FM. ‘Engineered Microenvironments to Direct Epidermal Stem Cell Behavior at Single-Cell Resolution.’ Dev Cell. 2016 Sep 26;38(6):601-9. doi: 10.1016/j.devcel.2016.08.010. Review. PMID: 27676433 [PubMed]

•  Natsuga K, Watt FM. ‘Galectin-6 is a novel skin anti-microbial peptide that is modulated by the skin barrier and microbiome.’ J Dermatol Sci. 2016 Oct;84(1):97-99. doi: 10.1016/j.jdermsci.2016.06.008. No abstract available. PMID: 27427436 [PubMed]

•  Weissman IL, Watt FM. ‘CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine.’ Cell Stem Cell. 2016 Jul 7;19(1):19-22. doi:10.1016/j.stem.2016.05.011. PMID: 27392224 [PubMed]

•  Rognoni E, Gomez C, Pisco AO, Rawlins EL, Simons BD, Watt FM, Driskell RR. 'Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.' Development. 2016 Jul 15. pii: dev.131797. PMID: 27287810 [PubMed]

•  Weissman IL, Watt FM. 'CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine.' Cell Stem Cell. 2016 Jul 7;19(1):19-22. doi: 10.1016/j.stem.2016.05.011. PMID: 27392224 [PubMed]

•  Natsuga K, Watt FM. 'Galectin-6 is a novel skin anti-microbial peptide that is modulated by the skin barrier and microbiome.' J Dermatol Sci. 2016 Jun 23. pii: S0923-1811(16)30125-6. doi: 10.1016/j.jdermsci.2016.06.008. PMID: 27427436 [PubMed]

•  Kerz M, Folarin A, Meleckyte R, Watt FM, Dobson RJ, Danovi D. 'A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data.' J Biomol Screen. 2016 Jun 2. pii: 1087057116652064. PMID: 27256155  [PubMed]

•  Elkenani M, Nyamsuren G, Raju P, Liakath-Ali K, Hamdaoui A, Kata A, Dressel R, Klonisch T, Watt FM, Engel W, Thliveris JA, Pantakani DV, Adham IM. 'Pelota Regulates Epidermal differentiation by Modulating BMP and PI3K/AKT Signaling Pathways.' J Invest Dermatol. 2016 May 6. pii: S0022-202X(16)31141-1. doi: 10.1016/j.jid.2016.04.020. PMID:27164299 [PubMed]

•  Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D, Protheroe HJ, Ingvorsen C, Galli A, Green A, Gleeson D, Ryder E, Glover L, Vizcay-Barrena G, Karp NA, Arends MJ, Brenn T, Spiegel S, Adams DJ, Watt FM, van der Weyden L. 'Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole body energy expenditure.' J Pathol. 2016 Apr 29. doi: 10.1002/path.4737. PMID:27126290 [PubMed]

•  Lichtenberger BM, Mastrogiannaki M, Watt FM. 'Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.' Nat Commun. 2016 Feb 3;7:10537. doi: 10.1038/ncomms10537. PMID:26837596 [PubMed]

•  Mastrogiannaki M, Lichtenberger BM, Reimer A, Collins CA, Driskell RR, Watt FM. 'β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis.' J Invest Dermatol. 2016 Feb 20. pii: S0022-202X(16)00489-9. doi: 10.1016/j.jid.2016.01.036. PMID:26902921 [PubMed]

•  Kretzschmar K, Weber C, Driskell RR, Calonje E, Watt FM. 'Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity.' Cell Rep. 2016 Jan 12;14(2):269-81. doi: 10.1016/j.celrep.2015.12.041. Epub 2016 Jan 7. PMID: 26771241 [PubMed]

•  Natsuga K, Cipolat S, Watt FM. 'Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility.' J Invest Dermatol. 2016 Jan;136(1):99-106. doi: 10.1038/JID.2015.383. PMID: 26763429 [PubMed]

•  Reimer A, Vasilevich A, Hulshof F, Viswanathan P, van Blitterswijk CA, de Boer J, Watt FM. 'Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells.' Sci Rep. 2016 Jan 13;6:18948. doi: 10.1038/srep18948. PMID: 26757610 [PubMed]

•  Weber C, Telerman SB, Reimer AS, Sequeira I, Liakath-Ali K, Arwert EN, Watt FM. 'Macrophage infiltration and alternative activation during wound healing promote MEK1-induced skin carcinogenesis.' Cancer Res. 2016 Jan 11. pii: canres.3676.2014. PMID: 26754935 [PubMed]

•  Watt FM. 'Professor Sir Henry Harris (1925-2014).' J Cell Sci. 2015 Dec 1;128(23):4253. PMID:26962590 [PubMed]

•  Viswanathan P, Guvendiren M, Chua W, Telerman SB, Liakath-Ali K, Burdick JA, Watt FM. 'Mimicking the topography of the epidermal-dermal interface with elastomer substrates.' Integr Biol (Camb). 2015 Dec 11. Viswanathan P, Guvendiren M, Chua W, Telerman SB, Liakath-Ali K, Burdick JA, Watt FM. PMID: 26658424 [PubMed]

•  Leha A, Moens N, Meleckyte R, Culley OJ, Gervasio MK, Kerz M, Reimer A, Cain SA, Streeter I, Folarin A, Stegle O, Kielty CM; HipSci Consortium, Durbin R, Watt FM, Danovi D. 'A high-content platform to characterise human induced pluripotent stem cell lines.' Methods. 2015 Nov 25. pii: S1046-2023(15)30153-5. doi: 10.1016/j.ymeth.2015.11.012. PMID: 26608109 [PubMed]

•  Natsuga K, Cipolat S, Watt FM 'Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility.' J Invest Dermatol. 2015 Sep 30. doi: 10.1038/jid.2015.383. PMID: 26422382 [PubMed]

•  Kaushal GS, Rognoni E, Lichtenberger BM, Driskell RR, Kretzschmar K, Hoste E, Watt FM. 'Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation.' J Invest Dermatol. 2015 Aug 19. doi: 10.1038/jid.2015.319. [Epub ahead of print] PMID: 26288357 [PubMed]

•  Kretzschmar K, Cottle DL, Schweiger PJ, Watt FM. 'The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells.' J Invest Dermatol. 2015 Jun 29. doi: 10.1038/jid.2015.242. [Epub ahead of print] PMID: 26121213 [PubMed]

•  Donati G, Watt FM. 'Stem Cell Heterogeneity and Plasticity in Epithelia.' Cell Stem Cell. 2015 May 7;16(5):465-476. doi: 10.1016/j.stem.2015.04.014. PMID: 25957902 [PubMed]

•  Hoste E, Cipolat S, Watt FM. 'Understanding allergy and cancer risk: what are the barriers?' Nat Rev Cancer. 2015 Mar;15(3):131-2. Epub 2015 Feb 5. PMID: 25866857 [PubMed]

•  Schekman R, Weigel D, Watt FM. 'Recognizing the importance of new tools and resources for research.' Elife. 2015 Mar 31;4. doi: 10.7554/eLife.07083. PMID: 25824292 [PubMed]

•  Smith KA, Arlotta P, Watt FM; Initiative on Women in Science and Engineering Working Group, Solomon SL. 'Seven actionable strategies for advancing women in science, engineering, and medicine.' Cell Stem Cell. 2015 Mar 5;16(3):221-4. doi: 10.1016/j.stem.2015.02.012. PMID: 25748929 [PubMed]

•  Driskell RR, Watt FM. 'Understanding fibroblast heterogeneity in the skin.' Trends Cell Biol. 2015 Feb;25(2):92-99. doi: 10.1016/j.tcb.2014.10.001. Epub 2014 Nov 7. PMID: 25455110 [PubMed]

•  Hoste E, Arwert EN, Lal R, South AP, Salas-Alanis JC, Murrell DF, Donati G, Watt FM. 'Innate sensing of microbial products promotes wound-induced skin cancer.' Nat Commun. 2015 Jan 9;6:5932. doi: 10.1038/ncomms6932. PMID: 25575023 [PubMed]

•  Watt FM. 'Mammalian skin cell biology: at the interface between laboratory and clinic.' Science. 2014 Nov 21;346(6212):937-40. doi: 10.1126/science.1253734. PMID: 25414300 [PubMed]

•  Kretzschmar K, Cottle DL, Donati G, Chiang MF, Quist SR, Gollnick HP, Natsuga K, Lin KI, Watt FM. 'BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor under Steady-State Conditions.' Stem Cell Reports. 2014 Oct 14;3(4):620-33. doi: 10.1016/j.stemcr.2014.08.007. Epub 2014 Sep 18. PMID: 25358790 [PubMed]

•  DiTommaso T, Jones LK, Cottle DL; WTSI Mouse Genetics Program, Gerdin AK, Vancollie VE, Watt FM, Ramirez-Solis R, Bradley A, Steel KP, Sundberg JP, White JK, Smyth IM. 'Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.' PLoS Genet. 2014 Oct 23;10(10):e1004705. doi: 10.1371/journal.pgen.1004705. eCollection 2014 Oct. PMID: 25340873 [PubMed]

•  Benaich N, Woodhouse S, Goldie SJ, Mishra A, Quist SR, Watt FM. 'Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis.' Cell Rep. 2014 Oct 9;9(1):104-17. doi: 10.1016/j.celrep.2014.08.062. Epub 2014 Oct 2. PMID: 25284788 [PubMed]

•  Patterson M, Schekman R, Watt FM, Weigel D. 'Advancing research.' Elife. 2014 Aug 13;3:e03980. doi: 10.7554/eLife.03980. PMID: 25122625 [PubMed]

•  Lane SW, Williams DA, Watt FM. 'Modulating the stem cell niche for tissue regeneration.' Nat Biotechnol. 2014 Aug 5. doi: 10.1038/nbt.2978. PMID: 25093887 [PubMed]

•  Kretzschmar K, Watt FM. 'Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin.' Cold Spring Harb Perspect Med. 2014 Jul 3. pii: a013631. doi: 10.1101/cshperspect.a013631. PMID: 24993676 [PubMed]

•  Driskell R, Jahoda CA, Chuong CM, Watt F, Horsley V. 'Defining dermal adipose tissue.' Exp Dermatol. 2014 May 19. doi: 10.1111/exd.12450. [Epub ahead of print] PMID: 24993676 [PubMed]

•  Cipolat S, Hoste E, Natsuga K, Quist SR, Watt FM. 'Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.' Elife. 2014 May 5;3:e01888. doi: 10.7554/eLife.01888. PMID: 24843010 [PubMed]

'Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.' Liakath-Ali K, Vancollie VE, Heath E, Smedley DP, Estabel J, Sunter D, Ditommaso T, White JK, Ramirez-Solis R, Smyth I, Steel KP, Watt FM. Nat Commun. 2014 Apr 11; 5:3540. doi: 10.1038/ncomms4540. PMID: 24721909 [PubMed]

•  'Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors.' Donati G, Proserpio V, Lichtenberger BM, Natsuga K, Sinclair R, Fujiwara H, Watt FM. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1501-9. doi: 10.1073/pnas.1312880111. Epub 2014 Mar 31. PMID: 24706781 [PubMed]

 

•  Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC, Watt FM. 'Distinct fibroblast lineages determine dermal architecture in skin development and repair' Nature 504, 277–281 (12 December 2013) doi:10.1038/nature12783 [Nature]

•  Lesko MH, Driskell RR, Kretzschmar K, Goldie SJ, Watt FM. 'Sox2 modulates the function of two distinct cell lineages in mouse skin.' Dev Biol. 2013 Aug 13. doi:pii: S0012-1606(13)00416-8. 10.1016/j.ydbio.2013.08.004.PMID: 23948231 [PubMed]

•  Ambatipudi S, Bhosale PG, Heath E, Pandey M, Kumar G, Kane S, Patil A, Maru GB, Desai RS, Watt FM, Mahimkar MB. 'Downregulation of Keratin 76 Expression during Oral Carcinogenesis of Human, Hamster and Mouse.' PLoS One. 2013 Jul 30;8(7):e70688. doi: 10.1371/journal.pone.0070688. Print 2013. PMID: 23936238 [PubMed]

•  White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC; Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP. 'Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes.' Cell. 2013 Jul 18;154(2):452-64. doi: 10.1016/j.cell.2013.06.022. PMID: 23870131 [PubMed]

•  Watt FM, Huck WT. 'Role of the extracellular matrix in regulating stem cell fate.' (2013) Nat Rev Mol Cell Biol. 2013 Jul 10. doi: 10.1038/nrm3620. PMID:23839578 [PubMed]

•  Tan KY, Lin H, Ramstedt M, Watt FM, Huck WT, Gautrot JE. 'Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns.' Integr Biol (Camb). 2013 Jun;5(6):899-910. doi: 10.1039/c3ib40026c. PMID: 23572192 [PubMed]

•  Tan DW, Jensen KB, Trotter MW, Connelly JT, Broad S, Watt FM. 'Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells.' Development. 2013 Apr;140(7):1433-44. doi: 10.1242/dev.087551. PMID: 23482486 [PubMed]

•  Watt FM. 'What does it take to recruit and retain senior women faculty?' Elife. 2013;2:e00615. doi: 10.7554/eLife.00615. Epub 2013 Mar 5. PMID: 23470921 [PubMed]

•  Cottle DL, Kretzschmar K, Schweiger PJ, Quist SR, Gollnick HP, Natsuga K, Aoyagi S, Watt FM. 'c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis.' Cell Rep. 2013 Feb 21;3(2):427-41. doi: 10.1016/j.celrep.2013.01.013. Epub 2013 Feb 9. PMID: 23403291 [PubMed]

•  Foijer F, DiTommaso T, Donati G, Hautaviita K, Xie SZ, Heath E, Smyth I, Watt FM, Sorger PK, Bradley A. 'Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells.' Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2928-33. doi: 10.1073/pnas.1217388110. Epub 2013 Feb 4. PMID: 23382243 [PubMed]

•  Lu L, Teixeira VH, Yuan Z, Graham TA, Endesfelder D, Kolluri K, Al-Juffali N, Hamilton N, Nicholson AG, Falzon M, Kschischo M, Swanton C, Wright NA, Carroll B, Watt FM, George JP, Jensen KB, Giangreco A, Janes SM. 'LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.' J Pathol. 2013 Mar;229(4):608-20. doi: 10.1002/path.4148. PMID: 23208928 [PubMed]

•  Trappmann B, Gautrot JE, Connelly JT, Strange DG, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM, Huck WT. 'Extracellular-matrix tethering regulates stem-cell fate.' (2012) Nat Mater. 11:742. doi: 10.1038/nmat3387. PMID: 22635042 [PubMed]

•  Mulder KW, Wang X, Escriu C, Ito Y, Schwarz RF, Gillis J, Sirokmány G, Donati G, Uribe-Lewis S, Pavlidis P, Murrell A, Markowetz F, Watt FM. 'Diverse epigenetic strategies interact to control epidermal differentiation.' (2012) Nat Cell Biol. 14: 753-63. PMID: 22729083 [PubMed]

•  Goldie SJ, Mulder KW, Tan DW, Lyons SK, Sims AH, Watt FM. (2012) 'FRMD4A Upregulation in Human Squamous Cell Carcinoma Promotes Tumor Growth and Metastasis and Is Associated with Poor Prognosis.' Cancer Res. 72: 3424-3346. PMID: 22564525 [PubMed]

•  Torres J, Prieto J, Durupt FC, Broad S, Watt FM. (2012) 'Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling.' PLoS One. 7:e36405. PMID: 22558462 [PubMed]

•  Gautrot JE, Wang C, Liu X, Goldie SJ, Trappmann B, Huck WT, Watt FM. (2012) 'Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis.' Biomaterials. 33:5221- 5229. PMID: 22541538 [PubMed]

•  Collins CA, Jensen KB, Macrae EJ, Mansfield W, Watt FM. (2012) 'Polyclonal origin and hair induction ability of dermal papillae in neonatal and adult mouse back skin.' Dev Biol. 366:290-297. PMID: 22537489 [PubMed]

•  Chhatriwala MK, Cipolat S, Sevilla LM, Nachat R, Watt FM. (2012) 'Exons 5-15 of Kazrin are dispensable for murine epidermal morphogenesis and homeostasis.' J Invest Dermatol. 132:1977-1987. PMID: 22513779 [PubMed]

•  Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB. (2012) 'Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.' Nat Cell Biol. 14:401-408. PMID: 22388892 [PubMed]

•  Arwert EN, Hoste E, Watt FM. (2012) 'Epithelial stem cells, wound healing and cancer.' Nat Rev Cancer.12:170-180. PMID: 22362215 [PubMed]

•  Kretzschmar K, Watt FM. (2012) 'Lineage tracing.' Cell. 148:33-45. PMID: 22265400 [PubMed]

•  Giangreco A, Hoste E, Takai Y, Rosewell I, Watt FM. (2012) 'Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity.' J Immunol. 188:1514-1522. PMID: 22210910 [PubMed]

•  Driskell RR, Juneja VR, Connelly JT, Kretzschmar K, Tan DW, Watt FM. (2011) 'Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo.' J Invest Dermatol. 132:1084-1093. PMID: 22189784 [PubMed]

•  Blanco S, Kurowski A, Nichols J, Watt FM, Benitah SA, Frye M. (2011) 'The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.' PLoS Genet. 7:e1002403. PMID: 22144916 [PubMed]

•  Watt FM. (2011) 'Stem cells: on the front line.' J Cell Sci. 124:3527-3528. PMID: 22083138 [PubMed]

•  Giangreco A, Lu L, Vickers C, Teixeira VH, Groot KR, Ilieva EV, George J, Nicholson AG, Sage EK, Watt FM, Janes SM. (2011) 'Beta-catenin determines upper airway progenitor cell fate and pre-invasive squamous lung cancer progression by modulating epithelial-to-mesenchymal transition.' J Pathol. 226:575-587. PMID: 22081448 [PubMed]

•  Connelly JT, Mishra A, Gautrot JE, Watt FM. (2011) 'Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation.' PLoS ONE. 6:e27259. PMID: 22073300 [PubMed]

•  Burdick JA, Watt FM. (2011) 'High-throughput stem-cell niches.' Nat Methods. 8: 915-916. PMID: 22036745 [PubMed]

•  Collins CA, Kretzschmar K, Watt FM. (2011) 'Reprogramming adult dermis to a neonatal state through epidermal activation of beta-catenin.' Development. 138:5189-5199. PMID: 22031549 [PubMed]

•  Arwert EN, Mentink RA, Driskell RR, Hoste E, Goldie SJ, Quist S, Watt FM. (2011) 'Upregulation of CD26 expression in epithelial cells and stromal cells during wound-induced skin tumour formation.' Oncogene. 31:992-1000. PMID: 21765471 [PubMed]

•  Hunziker L, Benitah SA, Braun KM, Jensen K, McNulty K, Butler C, Potton E, Nye E, Boyd R, Laurent G, Glogauer M, Wright NA, Watt FM, Janes SM (2011) 'Rac1 deletion causes thymic atrophy.' PLoS ONE. 6:e19292. PMID: 21559396 [PubMed]

•  Driskell RR, Clavel C, Rendl M, Watt FM. (2011) 'Hair follicle dermal papilla cells at a glance.' J Cell Sci. 124:1179-1182. PMID: 21444748 [PubMed]

•  Watt FM, Fujiwara H. (2011) 'Cell-extracellular matrix interactions in normal and diseased skin.' Cold Spring Harb Perspect Biol. 3; pii: a005124. PMID: 21441589 [PubMed]

•  Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM. (2011) 'The basement membrane of hair follicle stem cells is a muscle cell niche.' Cell. 144:577-589. PMID: 21335239 [PubMed]

•  Cho K, Vaught TG, Ji H, Gu D, Papasakelariou-Yared C, Horstmann N, Jennings JM, Lee M, Sevilla LM, Kloc M, Reynolds AB, Watt FM, Brennan RG, Kowalczyk AP, McCrea PD. (2010) 'Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.' J Cell Sci. 123:4128-4144. PMID: 21062899 [PubMed]

•  Arwert EN, Lal R, Quist S, Rosewell I, van Rooijen N, Watt FM. (2010) 'Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate.' Proc Natl Acad Sci USA. 107:19903-19908. PMID: 21041641 [PubMed]

•  Ambler CA, Watt FM. (2010) 'Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of Jagged 1.' Development. 137:3569-3579. PMID: 20940224 [PubMed]

•  Connelly JT, Gautrot JE, Trappmann B, Tan DW, Donati G, Huck WT, Watt FM. (2010) 'Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions.' Nat Cell Biol. 12:711-718. PMID: 20581838 [PubMed]

•  Jensen KB, Driskell RR, Watt FM. (2010) 'Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis.' Nat Protoc. 5:898-911. PMID: 20431535 [PubMed] [Download PDF (1.7 MB)]

•  Baker CM, Verstuyf, Jensen KB, Watt FM. (2010) 'Differential sensitivity of epidermal cell subpopulations to beta-catenin induced ectopic hair follicle formation.' Dev Biol. 343:40-50. PMID: 20398648 [PubMed]

•  Frye M, Dragoni I, Chin SF, Spiteri I, Kurowski A, Provenzano E, Green A, Ellis IO, Grimmer D, Teschendorff A, Zouboulis CC, Caldas CC, Watt FM. (2010) 'Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.' Cancer Letts. 12:711-718. PMID: 19740597 [PubMed]

•  Giangreco A, Goldie SJ, Failla V, Saintigny G, Watt FM. (2010) 'Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP.' J Invest Dermatol. 130:604-608. PMID: 19776755 [PubMed]

•  Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM, Huck WT. (2010) 'Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale.' Biomaterials. 31:5030-5041. PMID: 20347135 [PubMed]

•  Berta MA, Baker CM, Cottle DL, Watt FM. (2010) 'Dose and content dependent effects of Myc on epidermal stem cell proliferation and differentiation.' EMBO Mol Med. 2:16-25. PMID: 20043278 [PubMed]

•  Watt FM, Driskell RR. (2010) 'The therapeutic potential of stem cells.' Phil Trans Roy Soc. 365:155-163. PMID: 20008393 [PubMed]

•  Watt FM, Jensen KB. (2009) 'Epidermal stem cell diversity and quiescence.' EMBO Mol Med. 1:260-267. PMID: 20049729 [PubMed]

•  Nachat R, Cipolat S, Sevilla LM, Chhatriwala M, Groot KR, Watt FM. (2009) 'KazrinE is a novel desmosome-associated liprin that colocalises with acetylated microtubules.' J Cell Sci. 122:4035-4041. PMID: 19843585 [PubMed]

•  Giangreco A, Jensen KB, Takai Y, Miyoshi J, Watt FM. (2009) 'Necl2 regulates epidermal adhesion and wound repair.' Development 136:3505-3514. PMID: 19783739 [PubMed]

•  Driskell RR, Giangreco A, Jensen KB, Mulder KW, Watt FM. (2009) 'Sox-2 positive dermal papilla cells specify hair follicle type in mammalian Epidermis.' Development. 136:2815-2823. PMID: 19605494 [PubMed]

•  Giangreco A, Arwert, EN, Rosewell IR, Snyder J, Watt FM, Stripp BR (2009) 'Stem cells are dispensable for lung homeostasis but restore airways after injury.' Proc Natl Acad Sci USA. 106:9286-9291. PMID: 19478060 [PubMed]

•  Jensen KB, Collins CA, Nascimento E, Tan DW, Frye M, Itami S, Watt FM. (2009) 'Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis.' Cell Stem Cell. 4:427-439. PMID: 19427292 [PubMed]

•  Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavaré S, Arakawa S, Shimizu S, Watt FM, Narita M. (2009) 'Autophagy mediates the mitotic senescence transition.' Genes Dev. 23:798-803. PMID: 19279323 [PubMed]

•  Ferreira M, Fujiwara H, Morita K, Watt FM. (2009) 'An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumours.' Cancer Res. 69:1334-1342. PMID: 19190332 [PubMed]

 

•  Watt FM, Collins CA. (2008) 'Role of Beta-catenin in epidermal stem cell expansion, lineage selection, and cancer.' Cold Spring Harb Symp Quant Biol. 73:503-512. PMID: 19022747 [PubMed]

•  Sevilla LM, Nachat R, Groot KR, Watt FM. (2008) 'Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation.' J Cell Sci. 121:3561-3569. PMID: 18840647 [PubMed]

•  Collins CA and Watt FM. (2008) 'Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling.' Dev Biol. 324:55-67. PMID: 18805411 [PubMed]

•  Janes SM, Ofstad TA, Campbell DH, Eddaoudi A, Warnes G, Davies D, Watt FM. (2008) 'P13-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation.' Cell Res. 19:328-339. PMID: 18766172 [PubMed]

•  Jensen KB, Jones J, Watt FM. (2008) 'A stem cell gene expression profile of human squamous cell carcinomas.' Cancer Letts. 272:23-31. PMID: 18657901 [PubMed]

•  Sevilla LM, Rana AA, Watt FM, Smith JC. (2008) 'KazrinA is required for axial elongation and epidermal integrity in Xenopus tropicalis.' Dev Dyn. 237:1718-1725. PMID: 18498100 [PubMed]

•  Watt FM, Estrach S, Ambler CA. (2008) 'Epidermal Notch signalling: differentiation, cancer and adhesion.' Curr Opin Cell Biol. 20:171-179. PMID: 18342499 [PubMed]

•  Pálmer HG, Martinez D, Carmeliet G, Watt FM. (2008) 'The vitamin D receptor is required for mouse hair cycle progression but not for maintenance of the epidermal stem cell compartment.' J Invest Dermatol. 128:2113-2117. PMID: 18337835 [PubMed]

•  Celso CL, Berta MA, Braun KM, Frye M, Lyle S, Zouboulis CC, Watt FM. (2008) 'Characterisation of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin.' Stem Cells. 26:1241-1252. PMID: 18308950 [PubMed]

•  Estrach S, Cordes R, Hozumi K, Gossler A, Watt FM. (2008) 'Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis.' J Invest Dermatol. 128:825-832. PMID: 17960184 [PubMed]

•  Watt FM, Frye M, Benitah SA. (2008) 'MYC in mammalian epidermis: how can an oncogene stimulate differentiation?' Nat Rev Cancer. 8:234-242. PMID: 18292777 [PubMed]

•  Torres J, Watt FM. (2008) 'Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3.' Nat Cell Biol. 10:194-201. PMID: 18223644 [PubMed]

•  Giangreco A, Qin M, Pintar JE, Watt FM. (2008) 'Epidermal stem cells are retained in vivo throughout skin aging.' Aging Cell. 7:250-259. PMID: 18221414 [PubMed]

•  Pálmer HG, Anjos-Afonso F, Carmeliet G, Takeda H, Watt FM. (2008) 'The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specific tumor type in adult epidermis.' PloS ONE. 3:e1483. PMID: 18213391 [PubMed]