stem cells in their environment

team >

davide danovi




Director, HipSci Cell Phenotyping


•  MD - Universita' degli studi di Milano (Milan, IT)

•  PhD - European Institute of Oncology (Milan, IT) / Open University (Milton Keynes, UK)

research project title

'Cell Phenotyping for the Human Induced Pluripotent Stem Cells Initiative'

core expertise

High content screening using stem cells

wattlab blog entries

•  Science Foo Camp @ Google - 24 August 2016

•  The Robots are coming (... or are they) - 06 June 2015

•  Three half conferences - 06 January 2015

•  3rd Annual Systems Microscopy Consortium meeting, Stockholm: extracting sunny features through the Swedish summer clouds - 06 June 2014


[Full PubMed List]

•  ‘Common genetic variation drives molecular heterogeneity in human iPSCs.’ Kilpinen H, Goncalves A, Leha A, Afzal V, Alasoo K, Ashford S, Bala S, Bensaddek D, Casale FP, Culley OJ, Danecek P, Faulconbridge A, Harrison PW, Kathuria A, McCarthy D, McCarthy SA, Meleckyte R, Memari Y, Moens N, Soares F, Mann A, Streeter I, Agu CA, Alderton A, Nelson R, Harper S, Patel M, White A, Patel SR, Clarke L, Halai R, Kirton CM, Kolb-Kokocinski A, Beales P, Birney E, Danovi D, Lamond AI, Ouwehand WH, Vallier L, Watt FM, Durbin R, Stegle O, Gaffney DJ. Nature. 2017 May 10. doi: 10.1038/nature22403 PMID: 28489815 [PubMed]

•  'A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data.' Kerz M, Folarin A, Meleckyte R, Watt FM, Dobson RJ, Danovi D. J Biomol Screen. 2016 Jun 2. pii: 1087057116652064. PMID: 27256155  [PubMed]

•  'A high-content platform to characterise human induced pluripotent stem cell lines.' Leha A, Moens N, Meleckyte R, Culley OJ, Gervasio MK, Kerz M, Reimer A, Cain SA, Streeter I, Folarin A, Stegle O, Kielty CM; HipSci Consortium, Durbin R, Watt FM, Danovi D. Methods. 2015 Nov 25. pii: S1046-2023(15)30153-5. doi: 10.1016/j.ymeth.2015.11.012. PMID: 26608109 [PubMed]

•  'Human pluripotent stem cells on artificial microenvironments: a high content perspective.' Viswanathan P, Gaskell T, Moens N, Culley OJ, Hansen D, Gervasio MK, Yeap YJ, Danovi D. Front Pharmacol. 2014 Jul 2;5:150. doi: 10.3389/fphar.2014.00150. eCollection 2014. PMID: 25071572 [PubMed]

•  'High-content screening identifies a sensitivity of glioblastoma stem cells to inhibition of Polo-like kinase 1.' Danovi D, Pollard SM, et al. PLoS One. 2013 Oct 30;8(10):e77053. doi: 10.1371/journal.pone.0077053. eCollection 2013. PMID: 24204733 [PubMed]

•  'High content screening of defined chemical libraries using normal and glioma-derived neural stem cell lines.' Danovi D (joint corresponding author), Folarin AF, Baranowski B, Pollard SM Methods in Enzymology 2012;506:311-29. PMID: 22341231 [PubMed]

•  'Imaging-based chemical screens using normal and glioma-derived neural stem cells.' Danovi D (joint corresponding author), Falk A, Humphreys P, Vickers R, Tinsley J, Smith AG, Pollard SM. Bioc Soc Trans. 2010 Aug;38(4):1067-71. PMID: 20659005 [PubMed]

•  'A genetic screen for anchorage-independent proliferation in mammalian cells identifies a membrane-bound neuregulin.' Danovi D, Cremona CA, Machado-da-Silva G, Basu S, Noon LA, Parrinello S, Lloyd AC. PLoS One. 2010 Jul 26;5(7):e11774 PMID: 20668675 [PubMed]

•  'Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens.' Pollard SM, Yoshikawa K, Clarke ID, Danovi D, Stricker S, Russell R, Bayani J, Head R, Lee M, Bernstein M, Squire JA, Smith A, Dirks P. Cell Stem Cell. 2009 Jun 5;4(6):568-80. PMID: 19497285 [PubMed]

•  'Myc represses transcription through recruitment of DNA methyltransferase corepressor.' Brenner C, Deplus R, Didelot C, Loriot A, De Smet C, Danovi D, Boon T, Pelicci PG, Amati B, Kouzarides T, de Launoit Y, Di Croce L & Fuks F EMBO J. 2005 Jan 26;24(2):336-46. PMID: 15616584 [PubMed]

•  'Amplification of Hdmx directly contributes to tumour formation by inhibiting p300-mediated p53 acetylation and activation.' Danovi D (joint first author), Meulmeester E, Pasini D, Migliorini D, Capra M. Frenk R, de Graaf P, Francoz S, Gasparini P, Gobbi A, Helin K, Pelicci PG, Jochemsen AG, Marine JC. Mol Cell Biol. 2004 Jul;24(13):5835-43. PMID: 15199139 [PubMed]

•  'Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.' Migliorini D, Denchi EL, Danovi D (joint first author) , Jochemsen A, Capillo M, Gobbi A, Helin K, Pelicci PG, Marine JC. Mol Cell Biol. 2002 Aug;22(15):5527-38. PMID: 12101245 [PubMed]

•  'Nucleophosmin regulates the stability and transcriptional activity of p53.' Colombo E, Marine JC, Danovi D, Falini B, Pelicci PG. Nat Cell Biol. 2002 Jul;4(7):529-33. PMID: 12080348 [PubMed]

•  'Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation.' Migliorini D, Danovi D, Colombo E, Carbone R, Pelicci PG, Marine JC. J Biol Chem. 2002 Mar 1;277(9):7318-23. PMID: 11744695 [PubMed]