stem cells in their environment

team >

kalle sipilä




Research Associate


•  M.Sc. 2012 in biochemistry, University of Turku, Finland

•  Ph.D. 2016 in biochemistry and biomedical science, Universitu of Turku, Finland

research project title

'Effects of inhibiting stromal proliferation and ECM remodelling on cancer progression '

core expertise

•  Oral cancer biology

•  Biochemical, molecular biological, and cell biological techniques

•  Extracellular matrix and receptor biology



[Full PubMed list]

•  'NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis.' Salameti V, Bhosale PG, Ames-Draycott A, Sipilä K, Watt FM. Oncotarget. 2019 Nov 26;10(63):6791-6804. doi: 10.18632/oncotarget.27306. eCollection 2019 Nov 26. PMID:31827722 | PMCID:PMC6887571 [PubMed]

•  'Fibroblast state switching orchestrates dermal maturation and wound healing.' Rognoni E, Pisco AO, Hiratsuka T, Sipilä KH, Belmonte JM, Mobasseri SA, Philippeos C, Dilão R, Watt FM (2018) Mol Syst Biol 14(8):e8174. PMID: 30158243 [PubMed]

•  'Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.' Kober KI, Cano A, Géraud C, Sipilä K, Mobasseri SA, Philippeos C, Pisco AO, Stannard A, Martin A, Salvador F, Santos V, Boutros M, Rognoni E, Watt FM (2018) PLoS One. 13(6):e0199679. PMID: 29953488 [PubMed]

•  'Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms.' Sipilä KH, Drushinin K, Rappu P, Jokinen J, Salminen TA, Salo AM, Käpylä J, Myllyharju J, Heino J (2018) J Biol Chem. 293(20):7645-7658. PMID: 29615493 [PubMed]

•  'An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis.' Liakath-Ali K, Mills EW, Sequeira I, Lichtenberger BM, Pisco AO, Sipilä KH, Mishra A, Yoshikawa H, Wu CC, Ly T, Lamond AI, Adham IM, Green R, Watt FM. Nature. 2018 Apr 11. doi: 10.1038/s41586-018-0032-3. [Epub ahead of print] PMID:29643507 [PubMed]

•  'Joint inflammation related citrullination of functional arginines in extracellular proteins.' Sipilä KH, Ranga V, Rappu P, Mali M, Pirilä L, Heino I, Jokinen J, Käpylä J, Johnson MS, Heino J (2017). Sci Rep 7(1):8246.

•  'Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.' Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT (2016) Cell Stem Cell 19(4):530-543.

•  ‘Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.’ Hayes TF, Benaich N, Goldie SJ, Sipilä K, Ames-Draycott A, Cai W, Yin G, Watt FM. Cancer Lett. 2016 Dec 1;383(1):106-114. doi: 10.1016/j.canlet.2016.09.014. PMID: 27693639 [PubMed]

•  'Extracellular citrullination inhibits the function of matrix associated TGF-β' Sipilä KH, Ranga V, Rappu P, Torittu A, Pirilä L, Käpylä J, Johnson MS, Larjava H, Heino J. Matrix Biol (2016) pii: S0945-053X(16)30019-1. doi: 10.1016/j.matbio.2016.02.008. PMID:26923761 [PubMed]

•  'Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with α2 integrin' Roche F, Sipilä K, Honjo S, Johansson S, Tugues S, Heino J, Claesson-Welsh L. Matrix Biol (2015) 48:89-99. * Equal contribution by first and last authors PMID:26051322 [PubMed]

•  'Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner' Sipilä K, Haag S, Denessiouk K, Käpylä J, Peters EC, Denesyuk A, Hansen U, Konttinen Y, Johnson MS, Holmdahl R, Heino J. FASEB J (2014) 28(8):3758-68. PMID:24823363 [PubMed]

•  'Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation' Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K, Pihlavisto M, Pentikäinen OT, Marjamäki A, Heino J. J Biol Chem. (2012) 287(53):44694-702. PMID:23132859 [PubMed]

•  'Molecular mechanism of alpha2beta1 integrin interaction with human echovirus' 1. Jokinen J, White DJ, Salmela M, Huhtala M, Käpylä J, Sipilä K, Puranen JS, Nissinen L, Kankaanpää P, Marjomäki V, Hyypiä T, Johnson MS, Heino J.  EMBO J (2010) 29(1):196-208. PMID:19927126 [PubMed]